Abstract
The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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COS Cells
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Chlorocebus aethiops
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacology*
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Humans
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Ligands
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Models, Molecular
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Molecular Structure
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Receptors, Serotonin, 5-HT3 / chemistry*
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Receptors, Serotonin, 5-HT3 / metabolism
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Small Molecule Libraries / chemical synthesis
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Fluorescent Dyes
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Ligands
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Receptors, Serotonin, 5-HT3
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Small Molecule Libraries